منابع مشابه
Direct oral anticoagulants: integration into clinical practice
The introduction of direct oral anticoagulants (OACs) for the treatment and prevention of thromboembolic disease represents a shift from the traditional vitamin K antagonist-based therapies, which have been the mainstay of treatment for almost 60 years. A challenge for hospital formularies will be to manage the use of direct OACs from hospital to outpatient settings. Three direct OACs-apixaban,...
متن کاملDirect Oral Anticoagulants and their Clinical Management
Submit Manuscript | http://medcraveonline.com Abbreviations: DOACs: Direct Oral Anticoagulants; DVT: Deep Venous Thrombosis; PE: Pulmonary Embolus; PBS: Pharmaceutical Benefits Scheme; PD: Pharmacodynamic; PK: Pharmacokinetics; TGA: Therapeutic Good Administration; PCC: Prothrombin Complex Concentrate; PT: Prothrombin Time; aPTT: Activated Atrial Thromboplastin Time; FDA: Food and Drug Administ...
متن کاملThe new oral anticoagulants in clinical practice.
Vitamin K antagonists were the only class of oral anticoagulants available to clinicians for decades. However, with the US Food and Drug Administration approval of new oral anticoagulants, such as dabigatran, rivaroxaban, and apixaban, clinicians now have a broader choice. Given the recent approval and availability of these medications, several questions arise while deciding which of them would...
متن کاملDirect oral anticoagulants: a guide for daily practice.
In recent years, small oral compounds that specifically block activated coagulation factor X (FXa) or thrombin (FIIa) have become alternatives to the anticoagulants that had been used for several decades. As of today, these direct oral anticoagulants (DOACs) include dabigatran etexilate (thrombin inhibitor) and apixaban, edoxaban and rivaroxaban (inhibitors of FXa). While there is no doubt that...
متن کاملPractical recommendations on incorporating new oral anticoagulants into routine practice.
The use of new oral anticoagulants (NOACs) is expected to rise significantly in upcoming years. Therefore, it is important to understand the potential uses, side effects, and management of these agents in routine practice. NOACs have major pharmacologic advantages over warfarin, including a rapid onset and offset of action, fewer drug interactions, and predictable pharmacokinetics. These agents...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 2014
ISSN: 0032-5473,1469-0756
DOI: 10.1136/postgradmedj-2013-132474